ENDpoiNTs publications

ENDpoiNTs have published the following articles:

  1. Lupu D, Andersson P, Bornehag CG, et al. The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity. Int J Mol Sci. 2020;21(11):3978. doi:10.3390/ijms21113978.
  2. Leemans M, Couderq S, Demeneix B, Fini JB. Pesticides With Potential Thyroid Hormone-Disrupting Effects: A Review of Recent Data. Front Endocrinol (Lausanne). 2019;10:743. doi:10.3389/fendo.2019.00743.
  3. López-Tobón A, Emanuele Villa C, Cheroni C. et al. Human Cortical Organoids Expose a Differential Function of GSK3 on Cortical Neurogenesis. Stem Cell Reports. 2019; 13(5):847-861. doi:
    Demeneix BA. Evidence for Prenatal Exposure to Thyroid Disruptors and Adverse Effects on Brain Development. Eur Thyroid J. 2019;8(6):283-292. doi:10.1159/000504668
  4. Cheroni C, Caporale N, Testa G. Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology. Molecular Autism, accepted for publication
  5. Krebs A, Waldmann T, Wilks MF, Van Vugt-Lussenburg BMA, Van der Burg B, Terron A, Steger-Hartmann T, Ruegg J, Rovida C, Pedersen E, Pallocca G, Luijten M, Leite SB, Kustermann S, Kamp H, Hoeng J, Hewitt P, Herzler M, Hengstler JG, Heinonen T, Hartung T, Hardy B, Gantner F, Fritsche E, Fant K, Ezendam J, Exner T, Dunkern T, Dietrich DR, Coecke S, Busquet F, Braeuning A, Bondarenko O, Bennekou SH, Beilmann M, Leist M. Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data. ALTEX - Alternatives to animal experimentation, 2019;36(4):682-699. doi: 10.14573/altex.1909271.
  6. Karreman, C., Kranaster, P. and Leist, M. SUIKER: Quantification of antigens in cell organelles, neurites and cellular sub-structures by imaging. ALTEX - Alternatives to animal experimentation, 2019; 36(3), pp. 518-520. doi: 10.14573/altex.1906251.
  7. Krebs, A., Nyffeler, J., Karreman, C., Schmidt, B. Z., Kappenberg, F., Mellert, J., Pallocca, G., Pastor, M., Rahnenführer, J. and Leist, M. Determination of benchmark concentrations and their statistical uncertainty for cytotoxicity test data and functional in vitro assays. ALTEX - Alternatives to animal experimentation, 2020; 37(1), pp. 155-163. doi: 10.14573/altex.1912021.
  8. Karreman, C., Klima, S., Holzer, A.-K. and Leist, M. CaFFEE: A program for evaluating time courses of Ca2+ dependent signal changes of complex cells loaded with fluorescent indicator dyes. ALTEX - Alternatives to animal experimentation, 2020; 37(2), pp. 332-336. doi: 10.14573/altex.2003191.
  9. Brüll, M., Spreng, A.-S., Gutbier, S., Loser, D., Krebs, A., Reich, M., Kraushaar, U., Britschgi, M., Patsch, C. and Leist, M. Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies. ALTEX - Alternatives to animal experimentation, 2020; 37(3), pp. 409-428. doi: 10.14573/altex.1911111.
  10. Dreser N, Madjar K, Holzer AK, et al. Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances. Arch Toxicol. 2020; 94(1):151-171. doi:10.1007/s00204-019-02612-5.
  11. Tanner, E., Unenge, M., Wikstrom, S., Lindh, C., Kiviranta, H., Gennings, C., Bornehag, CG. (2020).Early Prenatal Exposure to Suspected Endocrine Disruptor Mixtures is Associated with Lower IQ at Age Seven. Env Int,
  12.  Brüll, Markus. 2020. Incorporation of stem cell-derived astrocytes into neuronal organoids to allow neuro-glial interactions in toxicological studies. ALTEX.10.14573/altex.1911111.
  13. Cheroni, Cristina; Cristina Cheroni; Nicolò Caporale; Nicolò Caporale; Giuseppe Testa; Giuseppe Testa.2020. Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology.Molecular Autism. 10.1186/s13229-020-00370-1.
  14. Snaidero, Nicolas; Martina Schifferer; Aleksandra Mezydlo; Bernard Zalc; Martin Kerschensteiner; Thomas Misgeld; Thomas Misgeld. 2020. Myelin replacement triggered by single-cell demyelination in mouse cortex..Nature Communications. 10.1038/s41467-020-18632-0.
  15. Loser, Dominik; Jasmin Schaefer; Timm Danker; Clemens Möller; Markus Brüll; Ilinca Suciu; Anna-Katharina Ückert; Stefanie Klima; Marcel Leist; Udo Kraushaar. 2020 .Human neuronal signaling and communication assays to assess functional neurotoxicity. Archives of Toxicology. 10.1007/s00204-020-02956-3.
  16. López-Tobón, Alejandro; Alejandro López-Tobón; Sebastiano Trattaro; Sebastiano Trattaro; Giuseppe Testa; Giuseppe Testa. 2020. The sociability spectrum: evidence from reciprocal genetic copy number variations..Molecular Autism. 10.1186/s13229-020-00347-0.
  17. Meisig, Johannes; Johannes Meisig; Nadine Dreser; Marion Kapitza; Margit Henry; Tamara Rotshteyn; Jörg Rahnenführer; Jan G. Hengstler; Agapios Sachinidis; Tanja Waldmann; Marcel Leist; Nils Blüthgen; Nils Blüthgen. 2020. Kinetic modeling of stem cell transcriptome dynamics to identify regulatory modules of normal and disturbed neuroectodermal differentiation. Nucleic Acids Research. 10.1093/nar/gkaa1089.
  18. Kappenberg, Franziska; Tim Brecklinghaus; Wiebke Albrecht; Jonathan Blum; Carola van der Wurp; Marcel Leist; Jan G. Hengstler; Jörg Rahnenführer. 2020. Handling deviating control values in concentration-response curves..Archives of Toxicology. 10.1007/s00204-020-02913-0.
  19. Dolde, Xenia; Christiaan Karreman; Marianne Wiechers; Stefan Schildknecht; Marcel Leist. 2021. Profiling of Human Neural Crest Chemoattractant Activity as a Replacement of Fetal Bovine Serum for In Vitro Chemotaxis Assays.International Journal of Molecular Sciences. 10.3390/ijms221810079.
  20. Loser, Dominik; Maria G. Hinojosa; Jonathan Blum; Jasmin Schaefer; Markus Brüll; Ylva Johansson; Ilinca Suciu; Karin Grillberger; Timm Danker; Clemens Möller; Iain Gardner; Gerhard F. Ecker; Susanne Hougaard Bennekou; Anna Forsby; Udo Kraushaar; Marcel Leist. 2021. Functional alterations by a subgroup of neonicotinoid pesticides in human dopaminergic neurons. Archives of Toxicology. 10.1007/s00204-021-03031-1.
  21. Klima, Stefanie; Markus Brüll; Anna-Sophie Spreng; Ilinca Suciu; Tjalda Falt; Jens Christian Schwamborn; Tanja Waldmann; Christiaan Karreman; Marcel Leist. 2021. A human stem cell-derived test system for agents modifying neuronal N -methyl- d -aspartate-type glutamate receptor Ca 2+ -signalling.Archives of Toxicology. 10.1007/s00204-021-03024-0.
  22. Loser, Dominik; Dominik Loser; Karin Grillberger; Maria G. Hinojosa; Jonathan Blum; Yves Haufe; Timm Danker; Ylva Johansson; Clemens Möller; Annette Nicke; Susanne Hougaard Bennekou; Iain Gardner; Caroline Bauch; Paul Walker; Anna Forsby; Gerhard F. Ecker; Udo Kraushaar; Marcel Leist. 2021. Acute effects of the imidacloprid metabolite desnitro-imidacloprid on human nACh receptors relevant for neuronal signaling. Archives of Toxicology. 10.1007/s00204-021-03168-z.
  23. Delp, Johannes; Andrea Cediel-Ulloa; Andrea Cediel-Ulloa; Ilinca Suciu; Petra Kranaster; Barbara M.A. van Vugt-Lussenburg; Vesna Munic Kos; Wanda van der Stel; Giada Carta; Susanne Hougaard Bennekou; Paul Jennings; Bob van de Water; Anna Forsby; Anna Forsby; Marcel Leist.2021.Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors.Delp , J , Cediel-Ulloa , A , Suciu , I , Kranaster , P , van Vugt-Lussenburg , B M , Munic Kos , V , van der Stel , W , Carta , G , Bennekou , S H , Jennings , P , van de Water , B , Forsby , A & Leist , M. 2021. Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors, Archives of Toxicology , vol. 95 , pp. 591–615 . 10.1007/s00204-020-02970-5.10.1007/s00204-020-02970-5.
  24. Demeneix, Barbara A. 2021. Environmental influences on brain aging.Aging Brain. 100003.10.1016/j.nbas.2020.100003.
  25. Audouze, Karine; Elias Zgheib; Khaled Abass; Asma H. Baig; Isabel Forner-Piquer; Henrik Holbech; Dries Knapen; Pim E. G. Leonards; Diana I. Lupu; Saranya Palaniswamy; Arja Rautio; Maria Sapounidou; Olwenn V. Martin. 2021. Evidenced-Based Approaches to Support the Development of Endocrine-Mediated Adverse Outcome Pathways: Challenges and Opportunities. Toxicol. 10.3389/ftox.2021.787017.
  26. Engdahl, Elin; Katherine Svensson; Ping-I Daniel Lin; Ali Alavian-Ghavaninic; Christian Lindh; Joëlle Rüegg; Carl-Gustaf Bornehag. 2021. DNA methylation at GRIN2B partially mediates the association between prenatal bisphenol F exposure and cognitive functions in 7-year-old children in the SELMA study. Environment International. 106617.10.1016/j.envint.2021.106617.
  27. Gerber, Lora-Sophie; Lennart V J van Melis; Regina G D M van Kleef; Aart de Groot; Remco H S Westerink. 2021. Culture of Rat Primary Cortical Cells for Microelectrode Array (MEA) Recordings to Screen for Acute and Developmental Neurotoxicity.Curr Protoc . e158.10.1002/cpz1.158.
  28. Marangon, Davide; Nicolò Caporale; Marta Boccazzi; Maria P. Abbracchio; Giuseppe Testa; Davide Lecca. 2021. Novel in vitro Experimental Approaches to Study Myelination and Remyelination in the Central Nervous System.Frontiers in cellular neuroscience. 10.3389/fncel.2021.748849.
  29. Klose, Jördis; Julia Tigges; Stefan Masjosthusmann; Katharina Schmuck; Farina Bendt; Ulrike Hübenthal; Patrick Petzsch; Karl Köhrer; Katharina Koch; Ellen Fritsche. 2021. TBBPA targets converging key events of human oligodendrocyte development resulting in two novel AOPs. ALTEX.10.14573/altex.2007201.